POLYMORPHISMS IN GENES ASSOCIATED WITH PRETERM BIRTH – A SYSTEMATIC REVIEW

Authors

  • Isabelle Weiss
  • Ana Isabela de Araujo Zotti
  • Isabela Cristina Santos Freire de Paula
  • Gisele de Paula Júlio Garcia
  • Nancy Marinho Barros
  • Izonete Cristina Guiloski
  • Bruna de Oliveira Rech
  • Cleber Machado-Souza

DOI:

https://doi.org/10.56083/RCV4N6-055

Keywords:

preterm births, biomarkers, single nucleotide polymorphisms, genes

Abstract

The assessment of maternal and fetal genetic susceptibility to preterm birth has been the focus of scientific research aimed at improving our understanding of the pathophysiology of prematurity, so this systematic review aimed to identify the main genes and single nucleotide polymorphisms (SNP) potentially associated with an increase in preterm births as gestational outcomes. A literature search was performed using PubMed, LILACS, Cochrane, Scopus, and Web of Science. A total of 19 studies were selected from 723 studies evaluated. The total number of SNPs presented in PTB was 54, and four SNPs were more frequent (rs1800629 [G/A] TNF; rs1800796 [G/C] IL6; rs16944 [A/G] IL1B; rs1800795 [G/C] IL6). This systematic review identified genes and SNPs related to PTB in the literature, which can be used in the future, as a basis for understanding and developing vulnerability tools to promote future preventive actions, with the aim of reducing the chance of preterm births.

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2024-06-07

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Weiss, I., Zotti, A. I. de A., Paula, I. C. S. F. de, Garcia, G. de P. J., Barros, N. M., Guiloski, I. C., Rech, B. de O., & Machado-Souza, C. (2024). POLYMORPHISMS IN GENES ASSOCIATED WITH PRETERM BIRTH – A SYSTEMATIC REVIEW . Revista Contemporânea, 4(6), e4248 . https://doi.org/10.56083/RCV4N6-055

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