O USO DA MORFINA COMO FATOR DE RISCO PARA O AUMENTO DA MORTALIDADE NO EDEMA AGUDO DE PULMÃO CARDIOGÊNICO.
DOI:
https://doi.org/10.56083/RCV2N3-016Keywords:
Pulmonary edema. Morphine. Mortality. Acute heart failure.Abstract
Cardiogenic pulmonary edema is caused by elevated pulmonary capillary hydrostatic pressure leading to transudation of fluid into the pulmonary interstitium and alveoli. For the management of acute cardiogenic pulmonary edema there is a standard treatment that includes the use of diuretics, nitroglycerin, oxygen and opioids (morphine). In recent years, the pros and cons of using morphine in acute pulmonary edema have been discussed, since the use of this drug can cause a serious adverse effect, which is respiratory depression, increasing mortality. The research method involved the descriptors “pulmonary edema”, morphine and mortality, which were searched in the Virtual Health Library (VHL) and Pubmed databases, finding a total of 68 articles. After the exclusion and inclusion criteria, 10 articles were chosen. In light of the reviewed articles, it was concluded that there is no literature proving the safety of morphine in acute cardiogenic pulmonary edema.
References
BOTELHO, L. L. R.; CUNHA, C. C. DE A.; MACEDO, M. O MÉTODO DA REVISÃO INTEGRATIVA NOS ESTUDOS ORGANIZACIONAIS. Gestão e Sociedade, v. 5, n. 11, p. 121 – 122. 2011. DOI: https://doi.org/10.21171/ges.v5i11.1220
CASPI, O. et al. Adverse dose-dependent effects of morphine therapy in acute heart failure. Crdiology, v. 13. 2019. DOI: https://doi.org/10.1016/j.ijcard.2019.06.015
CHIONCEL, O.; MIRO, O. Morphine in acute heart failure: Feeling better or living longer? Accepted Manuscript, v. 19. 2019. DOI: https://doi.org/10.1016/j.ijcard.2019.07.021
DOMINGUEZ, R. A, et al. Influencia del tratamiento con morfina en la mortalidad intrahospitalaria de pacientes con insuficiencia cardíaca aguda. Med Intensiva, v. 15. 2016.
ELLINGSRUD, C.; AGEWALL, S. Morphine in the treatment of acute pulmonary oedema — Why? International Journal of Cardiology, v. 202, p. 870–873, 2016. https://doi.org/10.1016/j.ijcard.2015.10.014 DOI: https://doi.org/10.1016/j.ijcard.2015.10.014
FERREIRA, V. et al. Uso de Opioides no Tratamento da Dor Crônica. Revista de psicologia, v. 14, n. 53, p. 522-534. 2020. DOI: https://doi.org/10.14295/idonline.v14i53.2797
GIL, V. et al. Morphine Use in the Treatment of Acute Cardiogenic Pulmonary Edema and Its Effects on Patient Outcome: A Systematic Review. Current Heart Failure Reports, v. 16, n. 4, p. 81–88. 2019. DOI: https://doi.org/10.1007/s11897-019-00427-0
HERMONT, A. P. et al. Revisões integrativas: conceitos, planejamento e execução. Arquivo Odontologia, v. 57, 2021.
JOHNSON, J. Management of Acute Cardiogenic Pulmonary Edema: A Literature Review. Advanced Emergency Nursing Journal, v. 31, n. 1, p. 36–43. 2009. DOI: https://doi.org/10.1097/TME.0b013e3181946fd8
KARIM, H. M. R.; ESQUINAS, A.; SINGHA, S. K. Morphine therapy in acute heart failure is associated with increased mechanical ventilation and mortality: Adverse dose-dependent effect or inevitable consequence? International Journal of Cardiology, v. 297. 2019. DOI: https://doi.org/10.1016/j.ijcard.2019.07.072
LIN, Y. et al. Intravenous morphine use in acute heart failure increases adverse outcomes: a meta-analysis. Rev. Cardiovasc, v. 22, n. 3. 2021. DOI: https://doi.org/10.31083/j.rcm2203092
MARIK, P E. Narrative Review: The Management of Acute Decompensated Heart Failure. Journal of Intensive Care Medicine, v. 27, n. 6. 2012. DOI: https://doi.org/10.1177/0885066611403260
MARTINS, H.; DAMASCENO, M.; AWADA, S. Pronto-Socorro. 3. ed. São Paulo: Manole, p. 207-217. 2012.
MIMO INVESTIGATORS et al. Study Design and Rationale of “A Multicenter, Open-Labeled, Randomized Controlled Trial Comparing MIdazolam Versus Morphine in Acute Pulmonary Edema”: MIMO Trial. Cardiovascular Drugs and Therapy, v. 31, n. 2, p. 209–213. 2017. DOI: https://doi.org/10.1007/s10557-017-6722-5
MIRO, O. et al. Influencia del tratamiento com morfina en la mortalidade intrahospitalaria de pacientes con insuficiencia cardíaca aguda. Carta científica, v. 10. 2016.
Opioids for persistent pain: summary of guidance on good practice from the British Pain Society. British Journal of Pain, v. 6, n. 1, p. 9–10, fev. 2012. DOI: https://doi.org/10.1177/2049463712436536
ORSO, D. et al. Is morphine safe in acute decompensated heart failure? A systematic review of the literature. European Journal of Internal Medicine, v. 69, p. e8–e10, nov. 2019. DOI: https://doi.org/10.1016/j.ejim.2019.08.016
SERINELLI, S. et al. Relationship between opiates and asthma in the determination of death. Journal of Forensic and Legal Medicine, v. 74, p. 102-30. 2020. DOI: https://doi.org/10.1016/j.jflm.2020.102030
SOSNOWSKI, M. Review article: Lack of effect of opiates in the treatment of acute cardiogenic pulmonary oedema. Emergency Medicine Australasia, v. 20, n. 5, p. 384–390. 2008. DOI: https://doi.org/10.1111/j.1742-6723.2008.01113.x
WHALEN, K.; FINKEL, R.; PANAVELIL, T. Farmacologia Ilustrada. 6. ed. Porto Alegre: Artmed Editora. 2016.
WRITING COMMITTEE MEMBERS et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): Developed in Collaboration With the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: Endorsed by the Heart Rhythm Society. Circulation, v. 112, n. 12, 20 set. 2005. DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.167587
ZANCANER, L. F. Edema Agudo de Pulmão na Sala de Urgência. Revista QualidadeHC, p. 2 - 3. 2018.
